German Cancer Research Center (DKFZ)

CONSORTIUM

The DKFZ is the largest biomedical research center in Germany with a worldwide reputation of excellence in basic and translational cancer research. Its strategic goals are to contribute towards a better understanding of fundamental processes in cancer and to develop innovative methods of cancer diagnostics and therapy. Research at the DKFZ is divided into six main research programs: Cell Biology and Tumor Biology; Structural and Functional Genomics; Cancer Risk Factors and Prevention; Immunology and Cancer; Imaging and Radiooncology; Infection, Inflammation and Cancer; and Translational Cancer Research.

It is the lead research center of the German Cancer Consortium, consisting of eight comprehensive cancer centers throughout Germany, with the mission of providing precision cancer medicine from basic research to personalized approaches to patient care.

Role in CCE_DART

The Division of Medical Image Computing has profound expertise and a substantial track record in the development and application of AI methods as well as in the question of how methods can be validated in benchmarks. In addition, the department has extensive experience with software development and infrastructure projects. It will lead the data sharing and analysis platform development and will contribute to the radiomics workflows with their expertise on medical image segmentation and object detection.

The Division of Translational Medical Oncology (TMO) contributes its expertise in molecularly guided precision oncology, especially in gathering and processing multi-omics data and assessing their clinical relevance. TMO’s multifaceted profile in translational cancer research is illustrated by the successful establishment of the cross-institutional NCT/DKTK MASTER program, the largest precision oncology trial in Germany. Drawing on a multidisciplinary workflow, more than 3,000 young adults with advanced cancer across histologies and patients with advanced rare cancers across age groups have undergone whole-exome/genome and transcriptome sequencing of their tumors and received individualized therapeutic recommendations by a dedicated molecular tumor board. The program is accompanied by a multitude of translational research projects.

 

The NCT Trial Center has profound expertise and a substantial track record in the development and conduct of clinical trials of phase I to III. In most trials, patient-reported outcomes and health care resource utilization are assessed. It also has a strong record in observational and registry studies.

The Division of Health Economics contributes to our understanding of the costs and cost-effectiveness of cancer care by establishing interdisciplinary collaborations both within the DKFZ and its networks, as well as with other German and international scientific institutions.

In close collaboration with the divisions of Medical Physics, Medical Informatics and Radiation Oncology, tools for tumor diagnosis and quantification of individual therapy responses are developed and applied. The Division of Radiology will be involved in the radiomics analysis as well as the collection and curation of prospective patient data.